Devarol: Vitamin D injection for osteoporosis

Devarol is one of the most popular medicines used for cases of vitamin D deficiency in adults and children. Below we learn all the important information that must be known before using it and the difference between it and the famous drug Sterogel.


  • This medicine is available in the form of ampoules for intramuscular injection.
  • Contains the active ingredient cholecalciferol.
  • It is used to prevent or treat vitamin D deficiency.
  • It is used only under the supervision of a doctor according to the medical condition.

What are the ingredients of Divarol S?


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It is a form of vitamin D3, and vitamin D plays essential roles in many parts of the body, including:

  • Intestine, where it increases its ability to absorb calcium and phosphate.
  • The skeleton, as it helps to increase bone strength thanks to its direct effect on bone formation and its effect on the parathyroid gland, as it reduces the level of parathyroid hormone (PTH), which causes the release of calcium from the bones into the blood.

Vitamin D is made naturally in the skin by exposure to sunlight, and it can also be found in certain foods such as fatty fish and eggs. The body needs vitamin D to maintain strong bones and muscles and to support immune system function.

One ampoule contains 2 ml of solution for intramuscular injection, and each 2 ml contains 5 mg of the active substance, equivalent to 200,000 international units.

What are the indications for the use of Divarol ampoule?

Devarol injection is used to prevent or treat vitamin D deficiency in the following cases:

  • Newborns.
  • Breastfeeding or pregnancy (last trimester of pregnancy).
  • the elderly.
  • Children and adolescents who are not exposed enough to the sun.
  • People under the influence of anticonvulsants, including phenytoin and primidone.
  • Long-term use of corticosteroids.
  • Gastrointestinal patients such as cases of intestinal malabsorption.
  • hepatic insufficiency;
  • Highly pigmented skin with an unbalanced diet.
  • Tuberculosis and leprosy patients.


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Divarol Vitamin D Injection

Vitamin D is important for regulating the amounts of calcium and phosphate in the body, which helps maintain healthy bones, teeth and muscles.

A deficiency in the level of vitamin D in the body causes many health problems, the most important of which are osteomalacia (in adults) and rickets (in children).

The main source for the formation of vitamin D inside the body is exposure to sunlight, but in periods of the year (such as winter) or as a result of lack of exposure to the sun or with some health problems, a deficiency of this vitamin may occur inside the body.

Vitamin D can be obtained in small amounts from some foods, including fatty fish, red meat, liver, and eggs.

This medicine contains vitamin D in a concentration that makes it very effective in treating moderate to severe vitamin D deficiency cases, but it is recommended to use it under medical supervision to determine the appropriate dose of the medicine according to the condition and the levels of vitamin D in the body.

Devarol for osteoporosis

Osteoporosis is one of the famous health conditions that cause bones to weaken and increase their susceptibility to fracture, and this condition develops over the years.

There are various causes of osteoporosis, including:

  • Family history of infection.
  • Lack of calcium and vitamin D in the body.
  • getting old.
  • Take some medications.

The use of vitamin D supplements helps regulate the level of calcium and phosphate in the body, which is important for patients with osteoporosis, as this helps to increase bone mass and strength so that it resists fracture and fragility.

Cases of fragility are diverse, and they have different degrees according to the severity of the injury. Taking supplements rich in calcium and vitamin D does not replace a visit to the doctor to confirm the condition and determine the appropriate treatment method according to each patient.

Devarol injection for the treatment of rickets

Rickets is a condition that affects the growth and development of bones in children, causing bone pain, growth retardation, and easy exposure to fractures, which may lead to bone deformities.

Rickets affects only children, but adults have a similar condition known as osteomalacia.

One of the most important causes of rickets is a deficiency in calcium or vitamin D. Therefore, in many of these cases, it may be recommended to use vitamin D and supplements that contain calcium to strengthen bones and protect children from rickets.

You should see a doctor to confirm the condition, as rickets may result from some genetic disorders, and the treatment will be determined according to the child’s condition and the degree to which his bones are affected.

Divarol injection for weight loss

Some evidence suggests that getting enough vitamin D can promote weight loss and reduce body fat.

Studies indicate conflicting results about the effect of vitamin D supplementation on weight. There are studies showing greater weight loss when using vitamin D supplements, and there are studies showing no weight loss when using vitamin D supplements.

Devarol is not used for the purpose of losing weight, but is only used to prevent or treat vitamin D deficiency, and the doctor determines the dose according to the percentage of vitamin D in the body and the patient’s condition.

What is the dose of Defarol? (devarol dose)

The dose varies according to the percentage of deficiency in patients and age group, and the usual doses are as follows:

Infants receiving vitamin D fortified milk: Half an ampoule (100,000 IU) every six months.

Babies who are breastfed or formula-fortified with vitamin D and children up to 5 years of age: 1 ampoule (200,000 IU) every six months.

Teenagers: 1 ampoule (200,000 IU) every six months during winter.

Pregnant women: Half an ampoule (100,000 IU) in the 6th and 7th month of pregnancy, and it can be repeated once a month if the last trimester of pregnancy starts in winter or in the absence of sun exposure.

Elderly: Half an ampoule (100,000 IU) every three months.

Children or adults with gastrointestinal diseases or who are undergoing antispasmodic therapy: Half to 1 ampoule (100,000 to 200,000 IU) every three months.

Children or adults in situations other than the above: 1 ampoule (200,000 IU) every six months.

Treatment of vitamin D deficiency (rickets, osteomalacia and hypocalcemia in newborns): 1 ampoule (200,000 IU) to be repeated once after 1 to 6 months.

How to use Devarol Injection?

  • Injections are taken intramuscularly according to the dosage prescribed by the doctor.
  • To avoid overdosage, the total dose of vitamin D should be taken into account if more than one supplement containing it is taken.
  • In the case of taking high doses of calcium, it is necessary to regularly monitor the level of calcium in the urine.

devarol side effects

This drug is usually used safely in doses specified according to each case, but excessive doses may cause side effects, including:

  • Headache.
  • weakness.
  • Anorexia.
  • Weight loss.
  • stunted growth.
  • Nausea.
  • vomiting.
  • frequent urination.
  • Extreme thirst or dehydration.
  • be kidney stones.
  • Kidney failure.

What are the contraindications of using Devarol?

  • Hypersensitivity to any of the ingredients of this medicine, especially vitamin D.
  • Excess calcium in the blood.
  • Excess calcium in the urine.
  • be kidney stones.

Defarol and pregnancy

There is no available study indicating the occurrence of abnormalities in the fetuses of animals when using the drug. Some studies suggest that vitamin D is unlikely to cause malformations in human fetuses.

This medication may be prescribed to treat vitamin D deficiency in the sixth and seventh months of pregnancy and may be repeated once a month, especially if the last trimester begins in winter.

You should consult your doctor before using this medicine or any other medicine during pregnancy.

Divarol and lactation

When necessary, this medicine can be used for breastfeeding women after consulting a doctor, especially those who breastfeed in late winter and spring.

Divarol injection for children

This medicine is used for children to prevent and treat rickets and other conditions resulting from a lack of vitamin D in the body, and the dose is determined according to the child’s condition and age.

Divarol for infants

This medicine is used for infants, but the doctor should be reviewed to determine the appropriate dose according to his health condition.

What are the drug interventions for the treatment of Defarol S?

It is advised to tell the doctor about the medications you usually take before using devarol 20000 to avoid adverse drug interactions, especially when:

  • Using other medicines containing vitamin D to avoid overdose.
  • Take calcium-rich supplements to avoid hypercalcemia.

What is an alternative to Defarol?

  • Vidrop.
  • Devit-3 Ampoules Devit-3.
  • Diviton.
  • One Alpha.
  • Breva D3.
  • D3 Candy.

What is the difference between Divarol and Sterogel?

Sterogel ampoules contain 600,000 IU of ergocalciferol, a form of vitamin D2 that helps the body regulate calcium absorption.

Devarol amp contains 200,000 IU of cholecalciferol which is a form of vitamin D3, which also regulates calcium absorption in the body.

It is available from Sterogyl ampoules for intramuscular injection (Sterogyl H) and another for oral administration (Sterogyl A), which is produced by Desma Pharma.

On the other hand, Divarol S, there is only one type available for intramuscular injection, and it is produced by Memphis Company for Pharmaceuticals and Pharmaceutical Industries.


The body produces vitamin D3 in response to exposure to sunlight, and it is also found in some foods as well as many nutritional supplements, but vitamin D2 is not manufactured inside the body, but is available in some plants such as mushrooms, and also in some nutritional supplements.

Vitamin D2 is less effective than vitamin D3 in treating deficiencies and raising the level of vitamin D in the body.

Do Devarol injections increase weight?

These injections do not usually cause weight gain in its users. On the contrary, one of the side effects resulting from its use in excessive doses is weight loss.

Is Divarol injections for weight loss?

Getting enough vitamin D may help promote weight loss, but this is still being studied and researched to confirm.

Does Defarol injection cause allergy?

It is not common to have an allergic reaction when using this medicine, but like other medicines, some patients may show hypersensitivity to it.

A life-threatening allergic reaction, which includes itching, redness, swelling of the tongue, and difficulty breathing, must be differentiated from normal pain at the site of an intramuscular injection.

Is Defarol S injection painful?

Injecting this medicine into the correct site usually does not cause severe pain, but it is normal to feel some pain and burning sensation after using it.

Can Devarol be taken orally?

This drug is designed to be used primarily intramuscularly, but doctors may prescribe oral use in some cases.

What is the price of Divarol ampoule?

The current price of the drug in Egypt is about 15 pounds.

Is Devarol available in tablets?

Tablets are not available from this drug, but the active substance in it may be available in other products as tablets with different trade names and varied according to the variety of producing companies.

What is the most popular alternative to Devarol Drops?

Vidrop is the most popular alternative available in the market in the form of drops to be taken by mouth, and its doses vary according to the condition and age of the patient.

What are the side effects of Divarol S?

The use of this drug may cause some side effects when used in high doses: high level of calcium in the blood and urine, loss of appetite and weight, feeling weak, thirst with frequent urination, and negatively affecting the kidneys.

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